«The developers of Swisstrace have long-standing experience in molecular imaging using radiotracers. The design of the systems is optimized for research using positron emission tomography»
Blood Sampler Twilite Three
The core of the twilite three system is a very compact measuring head machined from medical grade tungsten, which shields the LYSO crystals from outside radiation and is fully MR compatible. The scintillations are conveyed to the photon detection unit via two flexible high efficieny light guides. This elegant design is without any electronics in the sensor head and thus avoids any potential problems of electromagnetic interference with other devices. Furthermore, this design minimizes any potential risks in human research experiments.
Data acquisition is performed with the dedicated PMOD module PSAMPLE via a TCP/IP interface. A touch-screen on the front-panel serves as the user interface, and also displays the current status and measured values.
The twilite three's performance is outstanding. The system shows excellent sensitivity, linearity and signal-to-noise, also in the presence of high external radiation.
Since its introduction, the twilite and twilite two have been installed at sites in Europe, North/South America, Canada, and Asia. In addition to clinical and preclinical PET and PET/CT sites, more and more sites equipped with PET/MR scanners are using the system for the acquisition of arterial input curves.
Twilite Three Specifications
Dimensions 80 x 62 x 56 mm (L x W x H). Approx. 6 kg
Material machined from solid Inermet (TM) tungsten
Scintillator LYSO Connection via two flexible light guides, standard length 2 m, up to 10 m upon request, 5+8 m for PET/MR with optical coupler
Sensitivity catheter ID 0.28 mm: 0.2 cps/kBq/ml (mouse)
catheter ID 0.58 mm: 0.8 cps/kBq/ml (rats)
catheter ID 1.00 mm: 2.4 cps/kBq/ml (human)
Linearity Full linearity up to 6000 cps,
deviation at 10000 cps: < 1 %
Photon deection device
Portable case containing photon counting device and acquisition electronics
Stand-alone operation possible for system check, calibration etc.
Touch screen with device status and current count values [cps]
Software PMOD, PSAMPLE module
System requirements: 64-bit OS (Windows 10, 8, 7, MacOSX, Linux), 4GB RAM
Sampling frequency 1 kHz maximum
Interface TCP/IP (wireless optional)
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Kramer et al. (2019). Pharmacokinetic evaluation of [18F]PR04.MZ for PET/CT imaging and quantification of dopamine transporters in the human brain. Eur J Nucl Med Mol Imaging. Epub ahead of print. PubMed
Fahlstrom et al. (2017). Correlation between regional cerebral blood flow based on simultaneously acquired arterial spin labelling MRI and 15O-water-PET using zero-echo-time-based attenuation correction. SNM Conference 2017 Abstract, Denver, CO, USA. JNM website
Rytkönen et al. (2017). Dynamic PET Imaging with Arterial Input Function of Lipoposysaccharide Induced Neuroinflammation in Rat. Poster at World Preclinical Congress 2017, Boston, MA, USA. PDF
Bolcaen et al. (2016). Kinetic Modeling and Graphical Analysis of 18F-Fluoromethylcholine (FCho), 18F-Fluoroethyltyrosine (FET) and 18F-Fluorodeoxyglucose (FDG) PET for the Fiscrimination between High-Grade Glioma and Radiation Necrosis in Rats. PLoS One 11(8):e0161845. PDF PubMed
Müller Herde et al. (2015). Quantitative positron emission tomography of mGluR5 in rat brain with [(18) F]PSS232 at minimal invasiveness and reduced model complexity. J Neurochem 133(3):330-42. PDF PubMed
Zhang et al. (2014). Comparison of cerebral blood flow acquired by simultaneous [15O]water positron emission tomography and arterial spin labeling magnetic resonance imaging. JCBFM 34(8):1373-1380. PDF PubMed
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